Mark Slack qualified as a doctor at the University of the Witwatersrand in South Africa. He then completed his postgraduate training at the University of Cape Town. He graduated from the College of Medicine of South Africa in Gynaecology, winning the Daubenton Gold Medal for the most distinguished candidate in the exams in the country.

He was previously head of Gynaecology and Urogynaecology at Addenbrooke's Hospital, University of Cambridge Teaching Hospitals Trust, Cambridge.

Mr. Slack has run an active research unit in Cambridge. He developed and introduced the Sacrospinous Fixation to the UK. This is now the most commonly performed procedure for prolapse in the United Kingdom. He has invented several procedures which were adopted and taken to global launch by international Medical Device companies. He has published over 100 peer reviewed papers, more than 25 book chapters and numerous national guidelines. He is a regular contributor on several National Radio and Television programs.

He is a Co-founder and Chief Medical Officer of CMR Surgical, a start-up company in Cambridge which has developed a novel surgical robot (Versius). This is now the second largest soft tissue robotic company in the world. In 2021 it had the highest private MedTech funding round in the world with a $660 million raise. The subsequent valuation gave it Unicorn status.

He was appointed the Ethicon travelling Professor in 2004 as well as the Sims Black Professorship of the RCOG.. He was recognised by the NIHR in 2015 with an award as one of the leading researchers in the UK for clinical research. In 2018, under his leadership the Urogynaecology unit in Cambridge achieved the highest accreditation score ever awarded by the Royal College of Obstetricians and Gynaecologists.  In 2021 he was awarded honorary fellowship of the Royal College of Surgeons and Physicians of Glasgow and the French Academy of Surgeons